The architectural plans were made by Baccio Pontinelli and the construction was supervised by Giovanino de'Dolci. The wall paintings were executed by Pietro Perugino, Sandro Botticelli, Domenico Ghirlandaio, Cosimo Rosselli, Luca Signorelli and their respective workshops, which included Pinturicchio, Piero di Cosimo and Bartolomeo della Gatta.
Michelangelo Buonarroti was commissioned by Pope Julius II della
Rovere in 1508 to repaint the ceiling; the work was completed between
1508 and 1512. He painted the Last Judgement over the altar, between
1535 and 1541, being commissioned by Pope Paul III Farnese.
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